Repositioning Antimalarial Drug Quinacrine To Enhance Carboplatin Sensitivity In Ovarian Cancer

Abstract

Based preliminary data and additional data generated by this project, we have determined that the antimalarial drug Quinacrine (QC) reduces cell viability and promotes chemotherapy induced cell death in an autophagy-dependent manner more extensively in chemoresistant cells compared to their isogenic chemosensitive control cells as quantified by the Chou-Talalay methodology. Overall, our results show for the first time that synergy with QC and carboplatin involves a complex interplay between AV and apoptosis in OVCa cells and is associated with upregulation of INP2, downregulation of p62, and simultaneous upregulation of CTSL only in resistant cells.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2019
Accession Number
AD1094815

Entities

People

  • Vijayalaksh Shridhar

Organizations

  • Mayo Clinic

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Oncology
  • Proteins

Fields of Study

  • Chemistry

Readers

  • Oncology (Cancer Research).
  • Parasitology and Pharmacology of Malaria.