Diagnosis of Late-Stage, Early-Onset, Small-Fiber Polyneuropathy

Abstract

The goal of this study is to determine the prevalence of longstanding early-onset small-fiber polyneuropathy (SFPN) in Veterans with Gulf War Illness and to translate this information clinically by developing and validating tools to diagnose SFPN more quickly and reliably. Study participants will undergo several tests to determine occurrence of SFPN, specifically Autonomic Function Testing and skin biopsy to detect morphology and count of nerve endings. These tests will be compared to a symptom evaluation questionnaire for SFPN, a neurological exam that measures muscle strength and the ability to feel different sensations, genomic markers specific to SFPN, and pupil measurements including diameter and constriction. Our new screening tools will provide a precise measure of SFPN in a less invasive, more rapid approach to diagnosing small-fiber polyneuropathy in Veterans with Gulf War Illness.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1094831

Entities

People

  • Jorge M Serrador

Organizations

  • Veterans Biomedical Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Biotechnology
  • Blood Flow
  • Cardiovascular Physiological Phenomena
  • Data Analysis
  • Health Services
  • Heart Rate
  • Institutional Review Board
  • Law
  • Maryland
  • Medical Personnel
  • Neuropathy
  • Patent Applications
  • Peripheral Nervous System
  • Persian Gulf Syndrome
  • Physical Examination (Medicine)
  • Professional Development

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.