Glutamate Receptor and Kynurenine Pathway Functioning in the Pathobiology of Gulf War Illness

Abstract

This project examines inflammatory pathway biomarkers obtained from cerebrospinal fluid (CSF) collected from 46 1990-1991 Gulf War veterans with (cases) and 23 without(controls) Gulf War Illness (GWI) (AIM 1), and test involvement of N-methyl-D-aspartate receptor (NMDAR) functioning in GWI by administering a single dose of ketamine to 19 cases and 19 controls (aim 2) while measuring EEG for NMDAR target engagement and assessment of GWI symptoms up to one week after the infusion. In 2019we focused on subject recruitment for aim 1. Using the Gulf War Registry, advertisements and outreach to veterans at the local VA medical center, we recruited16 subjects for the study in 2019. Of those, 13 (10 cases) completed study procedures,with 7 subjects (4 cases) providing a sample of CSF.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1094898

Entities

People

  • Marijn Lijffijt

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Department Of Defense
  • Electronic Mail
  • Glutamates
  • Inflammation
  • Information Operations
  • Infusions
  • Ketamine
  • Kynurenine
  • Neuroglia
  • Patent Applications
  • Persian Gulf Syndrome
  • Professional Development
  • Standards
  • Technology Transfer

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neuroscience