LIGHT-ing Up Prostate Cancer for Immunotherapy
Abstract
Recent discoveries have demonstrated that the expression of LIGHT molecules within the tumor milieu counteracts cancer immune-evasion mechanisms and instigates activation and migration of T-cells into the tumor; however, the delivery of LIGHT to the tumor microenvironment has been a challenge. The overall goal of this project is to develop a targeted therapy that will deliver LIGHT to the tumor microenvironment by generating bispecific fusion proteins that are one-part LIGHT and one-part tumor-vasculature targeting moieties (VTP). We show in the final report here that nanogram-dose LIGHT-VTP is able to reduce tumor burden and improve survival in mice bearing prostate cancer tumors, and that combination treatment of low-dose LIGHT-VTP with a therapeutic vaccine results in complete tumor clearance. The funding from this project has allowed us to submit two separate articles on the topic and provide preliminary support for a newly awarded grant to continue the study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2019
- Accession Number
- AD1094914
Entities
People
- Wijbe M. Kast
Organizations
- University of Southern California