Neuromodulation and Neurorehabilitation for Treatment of Functional Deficits after mTBI plus PTSD
Abstract
It is estimated that 12-16 of veterans suffer a mild traumatic brain injury (mTBI) during deployment. This can result in persistent symptoms causing persistent disability. Moreover, incidence of post-traumatic stress disorder (PTSD) is increased among veterans with mTBI. Unfortunately there are few to no treatments that induce or accelerate functional recovery after mTBI. This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation (TMS) and (ii) determine how APT iTBS changes the neurocognitive system of attention in individuals with persistent attention deficits related to mTBI and PTSD. Previous studies have shown that iTBS can produce alterations in cerebral function that facilitate learning and recovery from neurologic injury. Specific Aim I will determine immediate effects of Active APT-III Active iTBS on neuropsychological measures of attention, measures of function and symptoms between baseline and endpoint. Aim II will determine sustainability and long-term of effects of Active APT III Active iTBS for neuropsychological, symptom and functional outcome measures, by comparing endpoint and 10-week post-treatment follow up.Aim III will determine how effects identified for Aims 1 and 2 relate to the underlying neurocognitive system of attention by examining the relationship between the functional and structural connectivity of the attention networks with the neuropsychological, functional and symptoms outcomes. Aim IV addresses the need to confirm safety of iTBS in this population.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1094917
Entities
People
- Theresa Pape