Prevention of Breast Cancer Skeletal Metastases with Parathyroid Hormone

Abstract

During this research period we have demonstrated that parathyroid hormone (PTH) started at the same time as intramammary implantation of murine 4T1-BGL breast cancer cells can decrease metastases to the skeleton but not to lung, liver or spleen. This is associated with changes in expression of metastasis genes in bone. We have further demonstrated that 4 weeks of PTH can decrease engraftment and growth of murine or human breast cancer cells injected into the intratibial bone marrow cavity. In preliminary studies we have demonstrated that knockdown of the PTH receptor PTH1R in 4T1 breast cancer cells abrogates the effect of PTH on reducing bone metastases, as does removal of PTH1R signaling in osteoblasts.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2019
Accession Number
AD1094956

Entities

People

  • Joy Y. Wu

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Bone And Bones
  • Bone Marrow
  • Bones
  • Breast Cancer
  • Cancer
  • Cells
  • Gene Expression
  • Health Services
  • Hormones
  • Lymphatic System
  • Medical Personnel
  • Neoplasms
  • Osteoblasts
  • Osteoporosis
  • Parathyroid Hormones
  • Proteins

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).