Monitoring Neurocognitive Performance and Electrophysiological Activity after Mild Traumatic Brain Injury

Abstract

Our project aimed to explore a wide variety of objective approaches to identify acute concussion (mTBI) patients and distinguish them from trauma controls that did not suffer head injury. Neuropsychometry, balance, actigraphy, electroencephalography (EEG), event related potentials (ERPs), magnetoencephalography (MEG), magnetic resonance imagining and spectroscopy (MRI and MRS), and blood biomarkers were evaluated. EEG, MEG, MRI, MRS, blood metalloproteinase-9, and blood fatty acid lipolysis all differed in mTBI, especially1-5 days after injury, and also differently at 30 days after injury. Preliminary analyses indicate the combination of techniques are even more informative than they are individually, especially combinations of EEG with blood lipids, MMP9, and MRI volumetrics and spectroscopy. The data suggest that further testing of these new objective EEG and blood biomarkers have the greatest potential for widespread utility.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2017
Accession Number
AD1094994

Entities

People

  • Michael G. Harrington

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cognition
  • Cognitive Workload
  • Head Injuries
  • Health Services
  • Information Processing
  • Medical Personnel
  • Neuroimaging
  • Psychology

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.