Discovery of Host Factors and Pathways Utilized in Hantaviral Infection

Abstract

Hantaviruses are negative-sense RNA enveloped viruses that are transmitted to humans in aerosols of rodent excreta. Hantaviral infections are associated with two significant human diseases: hemorrhagic fever with renal syndrome (HFRS) which is caused by Old World viruses found in Europe and Asia (Hantaan, Seoul, Puumala and Dobravaviruses) or hantavirus pulmonary syndrome (HPS) caused by the New World viruses of the Americas (Sin Nombre and Andes viruses). A goal of this project is to utilize high throughput genetic screens to define common cellular pathways, and broadly effective inhibitors targeting these pathways, that impact numerous hantaviruses. In the longer run, we hypothesize that the host factors identified by the proposed research will lead to new druggable targets for combating hantaviral infection.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1095032

Entities

People

  • Paul Bates

Tags

DTIC Thesaurus Topics

  • Bunyaviridae Infections
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Infection
  • Inhibitors
  • Medical Personnel
  • Proteins
  • Rna Stability
  • Students
  • Targeting
  • Vaccines
  • Virion
  • Viruses
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Oncology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology