The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

Abstract

The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in the regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells (DTCs) stay dormant for long periods of time. We postulate that DTCs drive the bone marrow niche into dormancy. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. During this period, we found that a slow-growing prostate cancer (PCa) may contribute to the maintenance of osteoblastic niche dormancy in vitro. In addition, we observed that a fast-growing osteoblast may have ability to induce bone metastatic PCa growth, and that a fast-growing osteoblast may enhance susceptibility of bone metastatic PCa to chemotherapy.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2019
Accession Number
AD1095045

Entities

People

  • Yusuke Shiozawa

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Bone And Bones
  • Bone Marrow
  • Bone Marrow Cells
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Skeleton
  • Stem Cells
  • Tissues

Readers

  • Data Mining and Knowledge Discovery.
  • Immunology and Pathology
  • Oncology