Optimizing Hemodynamic Support of Acute Spinal Cord Injury Based on Injury Mechanism
Abstract
This grant is focused on the augmentation of MAP with vasopressors and determining how such MAP augmentation would best be implemented (during compression, after decompression, or both). In YEAR 2 of this grant we finalized the comparison of two commonly used vasopressors, norepinephrine (NE) and phenylephrine (PE) after SCI. As our data suggested NE would better maintain elevated MAPs, using NE, in YEAR 3 we studied our first animal surgeries as part of Aim 1-3 to determine the impact of MAP augmentation during compression and/or decompression, on tissue hemodynamics within the spinal cord after a traumatic SCI. In YEAR 4, we finalized a draft manuscript on the role of vasopressor support in SCI. Furthermore, in YEAR 4 we sent human and pig CSF and serum sample to UofA for metabolomic and lipidomic profiling as part of TASK 3 of AIM 2 and 3. Although, conclusive results on the lipidomics/metabolomics work was not available prior to this report, we are committed to completing the analysis within the next few months (the microdialysis samples have been collected and sent to Dr. Li we just await the actual mass spectrometry analysis).
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 29, 2018
- Accession Number
- AD1095128
Entities
People
- Brian K Kwon
Organizations
- University of British Columbia