Stroma-Based Prognosticators Incorporating Differences between African and European Americans

Abstract

Our objective was to use standard Formalin-fixed Paraffin-embedded (FFPE) tissue to identify RNAs in prostate tumor-adjacent stroma that distinguish between cancers in European Americans (EA) and African Americans (AA), and to determine which fraction of these differences were associated with DNA methylation and/or protein changes. Gleason Score, chemical relapse status, and approximate age, were used to match AA with EA patients. We found striking differences in interferon stimulated genes between AA and EA tumor-adjacent stroma, of potential value as prognostic and therapeutic targets. To establish an in vitro test-bed for these observations, it became necessary to developed a valuable resource of new normal and cancer-associated fibroblast cell cultures. The advances made in this project are the basis of a funded five year follow-up grant.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1095167

Entities

People

  • Dan Mercola
  • Michael Mcclelland
  • Mike Lilly

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biological Sciences
  • Carrier Proteins
  • Cells
  • Chemistry
  • Data Analysis
  • Machine Learning
  • Medical Personnel
  • Methylation
  • Minority Groups
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Students
  • Therapy
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.