Elastomeric Auxetic Urogential Meshes: Exploring Alternatives to Knitted Polypropylene
Abstract
We developed novel synthetic prolapse meshes based on auxetic pore geometries (ie the pores expand rather than contract when loaded)manufactured from soft elastomers (polydimethysiloxane, PDMS, and polycarbonate urethane, PCU). This is contrary to current polypropylene meshes in which the pores collapse with loading and they are manufactured from stiff polypropylene. The purpose of this study was to test the hypothesis that the novel elastomeric, auxetic prolapse meshes will evoke improved tissue integration and preserve vaginal function relative to current commonly used polypropylene prolapse meshes. To test this hypothesis, we developed and validated a rabbit model for implanting mesh onto the internal vagina of a rabbit via a lumbar colpopexy. Furthermore, we were able to reproduce one of the most common mesh complications - a mesh exposure corroborating the utility of the rabbit as a model for understanding mesh complications. Following implantation for 3 months onto the rabbit vagina, the PDMS mesh had the least negative impact on the vagina. The PCU mesh impacted the rabbit vagina similar to Restorelle. Collectively, these results suggest that the host response to mesh is more sensitive to the polymer and further optimization of the design of the mesh is warranted. The results of this study were used as preliminary data in an NIH R01 application which was successfully funded in February 2019 (NICHD R01HD097187). Additionally, the results of this study were published in two peer-reviewed manuscripts (a third manuscript is in preparation) and discussed in over 20 scientific local and national meetings/seminars/conferences.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2020
- Accession Number
- AD1095171
Entities
People
- Pamela Moalli
- Rui Liang
- Steve Abramowitch
Organizations
- Magee-Womens Research Institute