Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy
Abstract
During the no-cost extension period we partially completed the Major Task 3. To evaluate the differences in immune landscapes between premalignancy and cancer, the tumor and premalignant microenvironments were assessed for CD3, CD4, CD8, CD11c, CD68, HLA-DR, TIM3, LAG3, Granzyme B, FOXP3, PD-1, PD-L1, Ki67 and cytokeratin expression utilizing multiplex immunofluorescence (MIF) staining. Thus, we significantly expanded the originally proposed immune marker panel, which will allow us to define the infiltrating immune cell landscapes with much higher resolution. The MIF data analysis is ongoing and will be completed utilizing other funding mechanisms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1095175
Entities
People
- Kostyantyn Krysan
Organizations
- University of California