A Closed-Loop Neural Prosthesis for Restoration of Function After Traumatic Brain Injury

Abstract

Significant progress has been made in developing activity-dependent stimulation (ADS) microdevices for use in both rodent and non-human primate (NHP) models of traumatic brain injury (TBI). Specifically, microdevices have been successfully assembled, benchtop tested for functionality, and deployed in a rodent model of TBI to determine the optimal time window for delivery of the therapy. Our preliminary results from a completed cohort of rodents indicate that we can delay ADS treatment for 1, 2 or 3 weeks after injury and still observe improvement in motor performance. Moreover, the functionality and versatility of software for the NHP microdevices has been successfully upgraded by adding several new features such as stimulus rate monitoring. In parallel, the design of the substrates for the head-mounted (rigid flexible)and backpack (all-rigid) portions of the NHP microdevice has been greatly advanced.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1095195

Entities

People

  • David J Guggenmos
  • Pedram Mohseni
  • Randolph J Nudo

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Brain Injuries
  • Computer Programming
  • Electrical Engineering
  • Electronic Components
  • Engineering
  • Governments
  • Humanities
  • Patent Applications
  • Professional Development
  • Prostheses And Implants
  • Students
  • Surgery
  • Training
  • User Interface
  • Wireless Communications

Readers

  • Integrated Circuit Design and Technology.
  • Neuroscience