Cell Communication in Antiestrogen Resistance

Abstract

More women die from the estrogen receptor positive (ER+) breast cancer subtype than from any other. The proportion of early ER+ recurrences (=5 years since diagnosis) approaches that for all triple-negative breast cancers alone. Late recurrences (greater than 5 years after diagnosis), the result of dormancy, are most common in ER+ disease and can arise decades after the initial diagnosis. Since recurrent breast cancers have escaped the effects of endocrine therapies, and are lethal, we will study endocrine resistance (Tamoxifen; Fulvestrant). Our primary objective is to identify what drives breast cancer growth and determine how to stop it. We will learn about why some breast cancers are aggressive and others are indolent, and why/how some breast cancers lay dormant for years and then re-emerge.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1095263

Entities

People

  • Robert Clarke
  • Yue Wang

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Algorithms
  • Alkenes
  • Bayesian Inference
  • Bayesian Networks
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Computational Biology
  • Culture Techniques
  • Data Analysis
  • Diseases And Disorders
  • Dynamics
  • Mathematical Models
  • Models
  • Multiscale Modeling
  • Neoplasms
  • Professional Development
  • Proteins
  • Resistance
  • Standards
  • Systems Biology
  • Therapy
  • Universities

Readers

  • Data Mining and Knowledge Discovery.
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.