Does Venous Thrombosis Chemoprophylaxis (VTC) Adversely Affect the Hemorrhagic Lesion in a Preclinical Model of Penetrating Traumatic Brain Injury

Abstract

Severe penetrating traumatic brain injury (TBI) patients represent the highest risk for complication associated with thromboembolism formation and hematoma expansion. Previous clinical studies demonstrated that the early use of VTC in these patients did not exacerbate intracerebral hematoma while reducing the risk of thromboembolism. Despite these findings, there is no consensus among neurosurgeons regarding its use in the presence of TBI, the appropriate timing or the dosing regimen. To address these issues, we propose to investigate the safety of VTC with regard to adversely affecting intracerebral hemorrhage in a rat model of penetrating TBI. The results of this study will potentially provide the scientific basis for modifying the clinical practice guidelines regarding the use of heparinoids for severe TBI in both civilian and military populations.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1095271

Entities

People

  • Anke H. Scultetus
  • Randy S. Bell
  • Zachary S. Bailey

Organizations

  • Walter Reed Army Institute of Research

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain Injuries
  • Cerebrovascular Disorders
  • Craniocerebral Trauma
  • Data Analysis
  • Embolism And Thrombosis
  • Health Services
  • Hemorrhage
  • Medical Personnel
  • Professional Development
  • Wounds And Injuries
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Neurological Diseases/Conditions/Disorders
  • Neurotrauma and Rehabilitation Medicine.
  • Trauma Surgery or Emergency Medicine.