Cancer-Associated Macrophagelike (CAML) Cells to Enhance Detection of Early-Stage Lung Cancer and Relapse After Definitive Treatment
Abstract
Lung cancer is the number one cause of cancer death in the United States. Low dose CT (LDCT) was recommended to screen for lung cancerfor smokers by the US Preventative Services Task Force. However, there are several problems with the current screening paradigm. Mostcritically, over 39% of screened subjects were determined to have positive screens with 96.4% false positive. This very high false positive rateresults in several critical problems including the requirement for further testing (scans, biopsies), the potential of loss to follow-up, thepossibility of false negative biopsy and the resultant patient stress and anxiety. While lung nodules <0.8 cm are considered low-risk findingsand nodules >3.0 cm high-risk, nodules between from 0.8-3.0 cm have been described as indeterminate and represent a managementchallenge. Therefore, there is a substantial need for a method to enrich the population of patients identified as likely to have malignancy andexclude those who have nodules not likely to have malignancy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2019
- Accession Number
- AD1095326
Entities
People
- Cha-Mei Tang