Microtubule-Based Therapy for Neurodegeneration in Gulf War Illness: Studies with hiPSC-Derived Neurons from Gulf War Veterans

Abstract

We have generated a bank of human induced pluripotent stem cells (hiPSCs) from the blood of Gulf War veterans (some with and some without Gulf War Illness), and we have conducted research on rat and human neurons on the microtubule-based mechanisms underlying neuronal deficits in GWI, thus enabling us to move forward on microtubule-based therapies. Toward the goal of rushing effective drug therapies to the sufferers of GWI, we propose to utilize the hiPSCs in rapid-throughput analyses of microtubule-active drugs that are either already FDA-approved or in advanced clinical trials.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1095345

Entities

People

  • Alvin V. Terry
  • Kimberly Sullivan
  • Liang Qiang
  • Peter W Baas
  • Rodrigo Espana

Organizations

  • Drexel University

Tags

DTIC Thesaurus Topics

  • Cells
  • Central Nervous System
  • Cytoskeleton
  • Diseases And Disorders
  • Embryos
  • Medical Personnel
  • Nervous System
  • Neurons
  • Persian Gulf Syndrome
  • Stem Cells
  • Students
  • Therapy

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and Cellular Biology
  • Neuroscience

Technology Areas

  • Biotechnology