Adult Tissue-Derived Stem Cells and Tolerance Induction in Nonhuman Primates for Vascularized Composite Allograft Transplantation

Abstract

Amputations and unsalvageable injuries with devastating tissue loss are common in the combat wounded. Reconstructive transplantation in the civilian setting using vascular composite allotransplants (VCA) composed of multiple tissues (skin, muscle, nerve, bone) in combination with long-term multidrug immunosuppression has been encouraging. However, the success of hand and face vascularized composite allografts (VCA) depends on high levels of immunosuppressive medications. The ability to minimize the high risks of both rejection episodes and immunosuppressive medications could allow for safer and more widespread VCA application to wounded service members.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2020
Accession Number
AD1095394

Entities

People

  • Eric A. Elster
  • Rolf N. Barth

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Arteries
  • Blood
  • Bone Marrow Cells
  • Cells
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Stem Cells
  • Surgery
  • Therapy
  • Transplants

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology