Operation Brain Trauma Therapy

Abstract

Operation brain trauma therapy (OBTT) is a groundbreaking, rigorous, multi-center pre-clinical drug biomarker screening consortium for traumatic brain injury (TBI). It is supported by 2 closely linked grants from DoD, i.e., WH81XWH-10-1-0623 and OBTT extended studies (WH81XWH-14). As requested, this final report is restricted to work on the parent OBTT grant WH81XWH-10-1 -0623. OBTT features testing in rat TBI models at the University of Pittsburgh, the Univ. of Miami, and WRAIR, in micro pig model at Virginia Commonwealth Univ., and biomarker studies at BanyanBiomarkers, Univ. of Florida, and Messina Univ. This grant supported testing of 8 drugs. Screening carried out in >1200 rats included standard outcomes and >5000 biomarker samples. Levetiracetam showed the most benefit (in 2 modles). Glibenclamide and amantadine showed model dependent benefit in contusion and penetrating brain injury. The biomarker GFAP performed well. OBTT produced 86 deliverables, including a full issue of J Neorotrauma. The biomarker data were well-received by FDA. OBTT is recognized as a pioneer in the TBI field.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2019
Accession Number
AD1095502

Entities

People

  • Patrick M. Kochanek

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Anticonvulsants
  • Biological Markers
  • Biomedical Research
  • Brain Injuries
  • Consortiums
  • Continents
  • Department Of Defense
  • Electronic Mail
  • Geographic Regions
  • Inventions
  • Patent Applications
  • Patents
  • Standards
  • Universities
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Research Science/Academic Research