Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans

Abstract

The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment (TBI-CI) in veterans and compare it to that of veterans with TBI with no CI (TBI), veterans with no TBI and CI (no TBI-CI),and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from CI without TBI and normal aging. Examining biomarkers in exosomes from the central nervous system, we found multiple blood-based biomarkers that differed significantly between the four groups.This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.

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Document Details

Document Type
Technical Report
Publication Date
Oct 29, 2018
Accession Number
AD1095505

Entities

People

  • Kristine Yaffe

Organizations

  • Northern California Institute for Research and Education

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Anxiety Disorders
  • Biological Markers
  • Brain
  • Brain Injuries
  • Central Nervous System
  • Cognitive Impairment
  • Dementia
  • Department Of Defense
  • Diseases And Disorders
  • Education
  • Electronic Mail
  • Medical Personnel
  • Nervous System
  • Proteins
  • Traumatic Stress Disorder

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