Tiered In Vitro Toxicity Testing of the Novel Energetic 1-methyl-2,4,5-trinitroimidazole (MTNI)

Abstract

The Army is identifying replacements for substances causing environmental and/or occupational risks. The IMTNI was evaluated in several in vitro test systems, including the Ames mutagenicity assay, the Microtox (registered trademark) Acute Toxicity Test System, and the human cell line activation test (h-CLAT) for skin sensitization. Data from the h-CLAT were also utilized to predict a Hazard Category for acute oral toxicity. The MTNI was found to be extremely toxic in all assays completed, mutagenic in the Ames, and a sensitizer in h-CLAT. The high aquatic toxicity combined with high solubility of MTNI causes concern for environmental and groundwater contamination. Additional aquatic testing should be conducted. Skin contact with MTNI should be avoided.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2020
Accession Number
AD1095733

Entities

People

  • Emily N. Reinke
  • Valerie H. Adams

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Cell Line
  • Cells
  • Department Of Defense
  • Environment
  • Environmental Protection
  • Groundwater
  • Health
  • International Organizations
  • Lactic Acid
  • Life Cycles
  • Materials
  • Materials Laboratories
  • Materials Testing
  • Medical Personnel
  • Molecular Structure
  • Munitions
  • Mutagenicity Tests
  • Plastic Explosives
  • Public Health
  • Range Finding
  • Regulations
  • Risk Analysis
  • Seizures
  • Standards
  • Technology Assessment
  • Test And Evaluation
  • Test Methods
  • Toxicity
  • Toxicology

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology