Spinal Cord Swelling and Alterations in Hydrostatic Pressure After Acute Injury

Abstract

In YEAR 4 we completed the statistical analysis of the existing duraplasty data as part of AIM 3 and are currently finalizing a manuscript on the role of duraplasty in a porcine model of SCI and its effects on intraparenchymal hemodynamics,metabolism, histological and behavioral recovery. Furthermore, as part of AIM 4, we evaluated the pressure inside the injured spinal cord (the spinal cord pressure, or SCP) and outside the injured spinal cord within the intrathecal space (the intraspinal pressure or ISP) using our pig model of SCI. We furthermore evaluate how their relationship to one another evolve with time over the first week post-injury, and how they may be influenced by location within the spinal cord relative to the site of injury. Lastly, we evaluated if CSF pressure, cord pressure, and spinal cord blood flow was associated with impairment or preservation of PRx.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2018
Accession Number
AD1095736

Entities

People

  • Brian K Kwon

Organizations

  • University of British Columbia

Tags

DTIC Thesaurus Topics

  • Animal Training
  • Arachnoid
  • Blood Flow
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Data Analysis
  • Gantt Charts
  • Hydrostatic Pressure
  • Measurement
  • Metabolism
  • Recovery
  • Regression Analysis
  • Spinal Cord
  • Spinal Injuries
  • Statistical Analysis
  • Training
  • Wounds And Injuries

Readers

  • Cardiovascular Physiology
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Space