Major Reassessment of the Fluid Percussion and Controlled Cortical Impact Models of Posttraumatic Epilepsy

Abstract

We have continued to provide strong evidence that SWDs in rats are unrelated to post-traumatic epilepsy (PTE), and our data now argue further that the SWDs are not absence seizures; instead, they appear to be normal brain oscillations widely present in a variety of common outbred laboratory rats, and even wild-caught rats. We have acquired increasingly strong evidence that early seizures, traditional epileptiform EEG spikes, and spikelets are not reliable PTE biomarkers for both the fluid percussion injury (FPI) and controlled cortical impact (CCI) models in rat. With the FPI model, we have obtained our first bona fide spontaneous recurrent seizures that appear to represent a true model of PTE, and these appear to be linked to preinjury stress.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1095828

Entities

People

  • Daniel S Barth
  • Edward Dudek

Organizations

  • Regents of the University of Colorado

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticonvulsants
  • Arteries
  • Brain
  • Brain Injuries
  • Computational Science
  • Data Analysis
  • Detection
  • Diseases And Disorders
  • Epilepsy
  • Experimental Design
  • Food Deprivation
  • Medical Personnel
  • Pattern Recognition
  • Psychology
  • Seizures
  • Supervised Machine Learning
  • Surgery

Readers

  • Canadian European Scientific Immigration and Epilepsy Clearance Studies
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology