Generation of a Suppressor tRNA-Mediated Antitumor Immune Response to Treat Ovarian Cancer
Abstract
In this project we were able to demonstrate that vaccination with lethally irradiated ovarian cancer cell lines that have been transfected with suppressor tRNAs protect against a subsequent challenge with live ovarian cancer cells. More importantly, vaccination with lethally irradiated ovarian cancer cell lines that have been transfected with suppressor tRNAs in animals that have been previously inoculated with live ovarian cancer cells reduced tumor growth (p less than 0.0001) and increased survival (p less than 0.0001) when compared to all the control groups. We were also able to develop a novel approach that will greatly facilitate the nature of neoantigen peptides on class I MHCs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2019
- Accession Number
- AD1095932
Entities
People
- Thomas Weber
Organizations
- Icahn School of Medicine at Mount Sinai