Targeting Neuromimicry in Prostate Cancer Metastasis

Abstract

The purpose of this project is to investigate the functional and mechanistic roles of a neural enzyme monoamine oxidase A (MAOA) and its downstream neuronal effectors in mediating prostate cancer-nerve reciprocal interactions and prostate cancer metastasis. Throughout the Year 2 of this study, we demonstrated that MAOA promotes perineural invasion of prostate cancer cells in 3D prostate cancer-nerve cell co-cultures and that MAOA inhibitor clorgyline suppresses prostate cancer cell perineural invasion in vitro. By analyzing orthotopic xenograft tumor samples generated from the Year-1 study, we also showed that MAOA promotes tumor cell proliferation and nerve density, which could be inhibited by the MAOA inhibitor clorgyline, in xenograft tumors.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2019
Accession Number
AD1095937

Entities

People

  • Boyang Wu

Organizations

  • Washington State University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Fluorescence
  • Fluorescent Dyes
  • Health Services
  • Inhibitors
  • Medical Personnel
  • Metastasis
  • Neoplasms
  • Nerves
  • Neurons
  • Prostate Cancer
  • Stem Cells
  • Xenografts

Fields of Study

  • Biology
  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience
  • Oncology (Cancer Research).