Toxicology Assessment for Department of Defense Strategic Environmental Research and Development Program (SERDP) Project WP 2601: Sustainable Environmentally Green Polyurethanes for Erosion-Resistant Coatings

Abstract

This Toxicology Assessment was conducted in accordance with ASTM Guideline E-2552. Compounds evaluated are part of an effort to develop non-isocyanate-based polyurethane coatings for protection of erosion-prone components of military equipment and aircraft, such as helicopter rotor blades. Eight perfluorinated compounds were evaluated. In most cases, experimental data were not available, so predictions were made using Quantitative Structure-Activity (QSAR) models. In common with other perfluorinated compounds, many of these compounds are predicted to be developmental or reproductive toxicants, and to be recalcitrant in the environment. Compounds structurally similar to bisphenol A are at least potential endocrine disruptors. The two most favorable compounds are 2-(difluoroiodomethyl)-2,3,3-trifluorooxirane and 2,2,3,3,4,4,5,5-octafluorohexane-1,6-diamine. In vitro experimental testing is recommended.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2019
Accession Number
AD1095942

Entities

People

  • William S. Eck

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

DTIC Thesaurus Topics

  • Department Of Defense
  • Endocrine Disruptors
  • Environment
  • Environmental Health
  • Environmental Protection
  • Experimental Data
  • Materials
  • Molecules
  • Mutagenicity Tests
  • Organic Compounds
  • Physical Properties
  • Polymers
  • Polyurethanes
  • Public Health
  • Synthetic Polymers
  • Toxicity
  • Toxicology

Readers

  • Groundwater Contamination Remediation.
  • Surface Coatings Technology.
  • Toxicology/Environmental Toxicology