Toward a Molecular Understanding of Noise Induced Hearing Loss

Abstract

The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have (a) Established the hair cell (HC) and supporting (SC) cell-specific translatome of adult mouse inner ears; (b) Established the molecular changes induced by PTS-resulting noise exposure in HC, SC and whole inner ears, 6 and 24 hours after noise exposure and began the TTS analysis; (c) We identified critical differences in the response of male and female mice to noise, and obtained approval to modify Specific Aim 3to focus on the response to Heat Shock profiling male and female mice, separately.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1095948

Entities

People

  • Ronna Hertzano

Organizations

  • University of Maryland School of Medicine

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Ear
  • Gene Expression
  • Genetic Structures
  • Genetics
  • Health Services
  • Hearing Disorders
  • Medical Personnel

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Molecular and Cellular Biology