Characterizing Myeloid Cell Activation in NF1 Vasculopathy
Abstract
Our original proposal seeks to understand the mechanisms underlying macrophage recruitment and activation in NF1-related vasculopathy. We have developed two mouse models that closely recapitulate NF1-related arterial stenosis and aortic aneurysm formation and propose to examine the contribution of MCP-1/CCR2 signaling and redox biology to these pathologies. As aneurysm and arterial stenosis represent two ends of a continuum, perturbations in macrophage recruitment and redox biology may underlie both pathologies; therefore, we have attempted to take a broad approach to both models in regards to these mechanisms. We have completed all proposed experiments, which have been described in several high-impact publications with multiple manuscripts undergoing Editorial Review for publication.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2019
- Accession Number
- AD1096040
Entities
People
- Brian K. Stansfield
Organizations
- Augusta University