Extremity Regeneration of Soft Tissue Injury Using Growth Factor-Impregnated Gels

Abstract

Nearly all experiments have been completed and a no cost extension has been approved inorder to complete all planned surgeries. A final surgery is scheduled for November, 2019 todetermine function of VEGF and VEGF + IGF1 in an ischemic-only injury. All other experimentsto evaluate the dose-response relationship, determine function of growth factor on nerveregeneration and function of each growth factor on independent nerve versus ischemicinjuries have been completed. There has been ongoing research and development on thealginate gels and growth factors through collaboration with the Wyss Institute. We have beenapproved to revise our statement of work, eliminating the pilot non-GLP studies. We arecompleting 4 GLP toxicity studies through an outside vendor with the Wyss Institute.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1096095

Entities

People

  • Simon G. Talbot

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Health Services
  • Lymphocytes
  • Materials Science
  • Medical Personnel
  • Residual Limbs
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Data Mining and Knowledge Discovery.
  • Trauma Surgery or Emergency Medicine.