Role of Tgf Beta and Wnt Signaling in Liver Tissue Homeostasis, Tumorigenesis, and Cancer

Abstract

During the funding period, we have generated a number of novel mouse models and genome editing tools to identify the cellular origins of liver cancer. These new tools have helped identify genes involved in regulating liver tumorigenesis. Thus, we have made progress towards advancing basic knowledge on the origin of liver cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1096097

Entities

People

  • Abby Sarkar
  • Eric Rulifson
  • Peng Wu
  • Roeland Nusse
  • Yinhua Jin

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Developmental Biology
  • Diseases And Disorders
  • Epithelial Cells
  • Genes
  • Homeostasis
  • Liver Diseases
  • Neoplasms
  • Regulators
  • Stem Cells
  • Targets
  • Technology Transfer
  • Transcription Factors
  • Two Dimensional

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Oncology