Development of Smoothened Agonist Non Phospholipid Liposomal Nanoparticles for Bone Repair

Abstract

Non-healing bone defects remain a significant problem for combat casualties and military veterans. A principle challenge is to develop therapeutic agents that safely and effectively improve growth and differentiation factor (GDF) based skeletal regeneration. The manipulation of Hedgehog signaling is a promising alternative to BMP2 for improved bone repair outcomes. Recently, we observed thatthe small molecule Hedgehog agonist SAG demonstrates pro-osteogenic / pro-vasculogenic effects to induce mouse calvarial defect healing. Independently, we have developed innately osteoinductive Stearylamine and Oxysterol (SA/Oxy) nanoparticles (NPs), and showed their high drug loading efficiency and synergistic osteoinductive potential with the small molecule SAG. In the current proposal, we willcombine these recent breakthroughs to develop a next generation NP packaged small molecule as a bone graft substitute product to jumpstart endogenous bone repair.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2019
Accession Number
AD1096483

Entities

People

  • Aaron W James

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone And Bones
  • Bone Marrow
  • Bone Regeneration
  • Cells
  • Cells (Biology)
  • Chemistry
  • Coatings
  • Department Of Defense
  • Electron Microscopy
  • Materials
  • Materials Processing
  • Medical Personnel
  • Membrane Lipids
  • Molecules
  • Nanomaterials
  • Nanoparticles
  • Nanotechnology
  • Osteogenesis
  • Peptide Growth Factors
  • Scanning Electron Microscopy
  • Small Molecules
  • Spectra
  • Stem Cells
  • Therapy
  • X Ray Photoelectron Spectroscopy
  • X Rays

Readers

  • Immunology and Pathology
  • Nanocomposite Materials Science
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech