Effect of Exertion on Adult Breathing Parameters: Literature Review and Meta-analysis
Abstract
The inhalation route is of particular concern for exposure to hazardous chemicals in the workplace and an important pathway for environmental exposures in everyday life. Physiologically based pharmacokinetic (PBPK) models have been proposed as tools for computation of internal dosimetry for both aggregate risk and cumulative risk. Among the stressors that are known to have an impact on the absorption, distribution, and elimination of chemicals are heat and exercise stress. The impact of these stressors on parameters used to describe inhalation was evaluated via literature review and synthesis. Data from up to 13 groups of healthy adult subjects were used to derive linear or second order polynomial relationships between exertion or heart rate and pulmonary ventilation rate, tidal volume, and breathing frequency. These relationships will allow future application of PBPK modeling-based strategies to prioritize among various cumulative risk scenarios involving chemicals and the many other stressors present in the workplace and other environments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 05, 2020
- Accession Number
- AD1096857
Entities
People
- Lisa Sweeney