IL 9 Producing Mast Cell Precursors and Food Allergy
Abstract
Food allergy is a harmful immune reaction driven by uncontrolled type-2 immune responses. Current knowledge provide limitedinsights into why only some, rather than all food allergic individuals are prone to develop life-threatening anaphylaxis. We haveidentified a novel multi-functional IL-9-producing mucosal mast cells (MMC9s) that produce large amounts of IL-9, IL-13, and mastcell mediators. The objective of this proposal is to identify the factors that regulate MMC9 induction, which represents the key cellularcheckpoint to develop food-induced anaphylaxis. The central hypothesis is that signals induced by IL-4 and antigen/IgE/FceRcomplex crosslinking act together to induce mast cell (MC) progenitors to develop into the pathogenic MMC9s, which amplifyanaphylactic response to dietary allergens. We have established genetically modified murine strains, a new reconstitution model ofexperimental food allergy, and the system to acquire duodenal biopsy samples from food allergic patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2019
- Accession Number
- AD1097354
Entities
People
- Andrew N. Smith
- Dana Shik
- Simon P Hogan
- Sunil Tomar
- Yui Hsi Wang