Tumor Slice Culture: A New Avatar in Personalized Oncology
Abstract
Cancer of the large intestine (colon and rectum) ranks the third most common and second most deadly in the United States. It affects Service members and their families as much as the civilian population. Sadly, approximately half of these patients develop metastatic disease (i.e. spread), most frequently to the liver, resulting in premature deaths. Scientific advances have led to a much better appreciation of the genetic changes (e.g. mutations) associated with the development and progression of colorectal cancer (CRC). Like most cancers, CRC differ from one another in their genetic make-up, clinical behavior, and treatment response. This holds true even within one tumor, which makes it challenging for physicians to choose the best treatment for individual patients. Despite the promise of personalized medicine to define the precise genetic landscape of each cancer, there remains an enormous gap between our knowledge of the genomic alterations harbored by a tumor, and how these changes affect the biology of the cancer and its response to drugs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2019
- Accession Number
- AD1097358
Entities
People
- Venu G Pillarisetty
Organizations
- University of Washington