Major Reassessment of the Fluid Percussion and Controlled Cortical Impact Models of Posttraumatic Epilepsy

Abstract

Our collaborative teams have continued to provide evidence in both animalmodels of traumatic brain injury (TBI) that spike-wave discharges (SWDs) inrats are not only not seizures, they are unrelated to post-traumaticepilepsy (PTE). Our data argue further that the SWDs are not absenceseizures; instead, they appear to be normal brain oscillations widelypresent in virtually all laboratory rats, and even wild-caught rats. We haveacquired increasingly strong evidence that early seizures, epileptiform EEGspikes, and spikelets are not reliable PTE biomarkers for both the fluidpercussion injury (FPI) and controlled cortical impact (CCI) models. Withthe FPI model, we have evidence from a pilot study that bonafide spontaneousrecurrent seizures may occur when pre-injury stress precedes the FPI-TBI,and we are conducting further studies on both the FPI and CCI models.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1097366

Entities

People

  • Daniel S Barth
  • Edward Dudek

Organizations

  • Regents of the University of Colorado

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticonvulsants
  • Arteries
  • Brain
  • Brain Injuries
  • Computational Science
  • Epilepsy
  • Information Science
  • Medical Personnel
  • Neurosciences
  • Pattern Recognition
  • Psychology
  • Seizures
  • Skull
  • Supervised Machine Learning

Readers

  • Military Logistics and Supply Chain Management
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.