Examination of Neuroimaging, Cognitive Functioning and Plasma Markers in a Longitudinal Cohort of Gulf War Deployed Veterans: The Ft. Devens Cohort

Abstract

This study aims to conduct follow-up longitudinal cognitive evaluations on a sub-sample of 100 Time 3 Ft. DevensCohort veterans, most of whom were last evaluated in-person for cognitive functioning and with neuroimaging inthe mid-1990s, to compare objective measurement of reported decline; and to determine cross-sectional blood andneuroimaging biomarkers (blood and structural volumetrics will also include longitudinal analyses) at 25+ yearspost deployment to the Gulf region, that may be consistent with cognitive outcomes and presumed pathobiologicalmechanisms (oxidative stress, ROS) of GWI. These data will evaluate the utility of previously unavailable bloodand neuroimaging markers of oxidative stress, to devise a new diagnostic test for GWI in subgroups of GW veterans(TBI and OP exposed), and to provide a potential objective biomarker of treatment efficacy in clinical trials.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1097369

Entities

People

  • Kimberly Sullivan

Organizations

  • Boston University School of Public Health

Tags

DTIC Thesaurus Topics

  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Central Nervous System
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Data Analysis
  • Diseases And Disorders
  • Health Services
  • Hypertension
  • Information Processing
  • Nervous System
  • Neuroimaging
  • Oxidative Stress
  • Persian Gulf Syndrome
  • Public Health
  • Surveys

Fields of Study

  • Medicine
  • Psychology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.