A Latent Variable Phenotype for Dementia Diagnosis and Biomarker Selection in TBI

Abstract

We proposed to assess dementia severity by telephone in veterans of operations Enduring Freedom and Iraqi Freedom (OEF /OIF) with Traumatic Brain Injury (TBI) using a latent dementia-specific phenotype constructed via a unique confirmatory bifactor model in a Structural Equation Model (SEM) framework (i.e., d for dementia). Logistical issues prevented us from recruiting our entire sample. Regardless, our approach proved successful. Two d composites administered by lay interviewers over the telephone accurately diagnosed cases of Mild Cognitive Impairment (MCI) in OEF /OIF veterans and were strongly associated with dementia severity as independently rated by an experienced clinician. Other analyses suggest that one of these composites is associated with self-reported TBI exposure. Future analyses with data in hand may relate our composite to serum protein and imaging biomarkers.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1097545

Entities

People

  • Donald R. Royall

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biological Markers
  • Biomedical Research
  • Blood Proteins
  • Brain Injuries
  • Cognitive Impairment
  • Composite Materials
  • Dementia
  • Diseases And Disorders
  • Genetics
  • Health Care
  • Health Services
  • Image Processing
  • Medical Personnel
  • Neuroimaging
  • Phenotypes
  • Proteins

Fields of Study

  • Psychology

Readers

  • Maritime Combat Support and Expeditionary Logistics.
  • Psychometric Testing or Psychological Assessment.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.