Novel Autoantibody Serum and Cerebrospinal Fluid Biomarkers in Veterans with Gulf War Illness
Abstract
The major goal of this study to develop objective peripheral biomarkers for Gulf War Illness (GWI). The following proposed specific aims have been accomplished. 1) Adapting our autoantibody assay to plasma. 2) An ELISA Assay of Autoantibodies Against Neural Proteins has been developed, 3) Comparative study of Biomarkers for Gulf War Illness (GWI), Chronic Fatigue Syndrome (CFS) and Irritable Bowel Syndrome (IBS) has been demonstrated. Only a few samples of cerebrospinal fluid became available for our study. We plan to collect more samples during the no-cost extension year that we requested and was approved. During this year, we plan to prepare several manuscripts and submit them for publication in peer-refereed journals (See details in the report). Our results confirm the continuing presence of autoantibodies against neural proteins in GW veterans and are in agreement with recent reports indicating that 29 years after the war, the health of veterans with GWI is not improving and may be getting worse. Such blood-based autoantibody tests have proven to be useful as biomarkers for various conditions of veterans of the 1990-1991 Gulf War such as Gulf War Illness (GWI), Chronic Fatigue Syndrome (CFS) and Irritable Bowel Syndrome (IBS). We plan to present results at scientific meetings and in peer-reviewed publications.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1097553
Entities
People
- Mohamed B. Abou-donia
Organizations
- Duke University