Enhancing the Prevention and Treatment of Orthopaedic Infections Associated with Traumatic Injury
Abstract
Injuries to the bone resulting from traumatic injury are highly susceptible to infection, and the resulting infections are therapeutically recalcitrant to antibiotic therapy. The overall goal of this project was to develop improved treatment methods that could be used to overcome this therapeutic recalcitrance. To this end, we evaluated existing antibiotics based on their efficacy in the specific context of a biofilm, took advantage of our knowledge regarding the pathogenesis of Staphylococcus aureus as a cause of bone infection to identify small molecule inhibitors of the staphylococcal accessory regulator (sarA), and explored methods to enhance the systemic delivery of the most efficacious antibiotics and effective sarA inhibitors directly to the bone. The ultimate goal was to then evaluate the efficacy of these novel approaches, alone and in combination with each other, in a relevant animal model of posttraumatic osteomyelitis. The first of these objectives was accomplished, and the second and third were extensively explored at an antimicrobial, anti-biofilm, and pharmacological basis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2019
- Accession Number
- AD1097747
Entities
People
- Mark S Smeltzer
Organizations
- University of Arkansas for Medical Sciences