Measurement of Various Respiratory Dynamics Parameters Following Acute Inhalational Exposure to Soman Vapor in Conscious Rats

Abstract

Respiratory dynamics were investigated in head-out plethysmography chambers following inhalational exposure to soman in untreated, non-anesthetized rats. A multipass saturator cell was used to generate 520, 560 and 600mgmin/m3 of soman vapor in a customized inhalational exposure system. Various respiratory dynamic parameters were collected from male Sprague-Dawley rats (300350 g) during (20 min) and 24 h (10 min) after inhalational exposure. Signs of CWNA-induced cholinergic crisis were observed in all soman-exposed animals. Percentage body weight loss and lung edema were observed in all soman-exposed animals, with significant increases in both at 24 h following exposure to 600mgmin/m3. Exposure to soman resulted in increases in respiratory frequency (RF) in animals exposed to 560 and 600mgmin/m3 with significant increases following exposure to 560mgmin/m3 at 24 h. No significant alterations in inspiratory time (IT) or expiratory time (ET) were observed in soman-exposed animals 24 h post-exposure. Prominent increases in tidal volume (TV) and minute volume (MV) were observed at 24 h post-exposure in animals exposed to 600mgmin/m3. Peak inspiratory (PIF) and expiratory flow (PEF) followed similar patterns and increased 24 h post-exposure to 600mgmin/m3 of soman. Results demonstrate that inhalational exposure to 600mgmin/m3 soman produces notable alterations in various respiratory dynamic parameters at 24 h. The following multitude of physiological changes in respiratory dynamics highlights the need to develop countermeasures that protect against respiratory toxicity and lung injury.

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Document Details

Document Type
Technical Report
Publication Date
Jul 24, 2015
Accession Number
AD1097871

Entities

People

  • Alfred M. Sciuto
  • Ashley Rodriguez
  • Benjamin Wong
  • Jennifer Devorak
  • Michael W. Perkins

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Airway Management
  • Body Weight
  • Brain
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Data Analysis
  • Data Science
  • Factor Analysis
  • Lung Diseases
  • Measurement
  • Nerve Agents
  • Nose
  • Rodents
  • United States Government

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