Integrin Regulation of Ferroptosis in Breast Cancer

Abstract

The hypothesis being tested in this proposal is that breast cancer cells, especially metastatic cells, are prone to rapid increases in ROS and lipid peroxidation caused by adverse micro-environmental conditions and that these oxidative bursts could have deleterious consequences including ferroptosis. Ferroptosis is defined as an iron-dependent, non-apoptotic form of programmed cell death characterized by the accumulation of intracellular soluble and lipid reactive oxygen species (ROS).For this reason, breast tumor cells must acquire mechanisms to protect against oxidative bursts and ferroptosis to metastasize.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2019
Accession Number
AD1098687

Entities

People

  • Arthur M Mercurio

Organizations

  • University of Massachusetts Medical School

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Medical Personnel
  • Molecular Biology
  • Programmed Cell Death

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Neurological Diseases/Conditions/Disorders
  • Oncology