The Function of Renal Macrophages in Lupus Nephritis
Abstract
This proposal addresses the Topic Area of Systemic Lupus Erythematosus (SLE or lupus), specifically lupus nephritis(LN). Lupus nephritis affects between 30-60% of adult SLE patients and is responsible for significant morbidity and mortality.Despite many advances in biologic drug therapy, no effective new therapy for LN has yet emerged and the reason why so many patients fail therapy is not known. Novel molecular datasets are beginning to be generated from single cells isolated from human LN kidney biopsies. In the first aim, we are successfully generating parallel datasets from the mouse models so that as pathways of interest are identified in the human samples they can quickly be modeled and their function clarified in the appropriate lupus pronemouse. Our second aim addresses the role of autophagy and metabolism in renal macrophages. We have found that deficiency of Rubicon protects the lupus mice from LN and death and are in the process of determining which immune cells are responsible for this protection. We have also investigated the role of PGC-1 in metabolic programming of kidney macrophages in LN. In this instance we have not been able to demonstrate a significant role for this transcriptional regulator in macrophages of LN kidneys.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1098704
Entities
People
- Anne Davidson
Organizations
- The Feinstein Institute for Medical Research