Soman-Induced Status Epilepticus, Epileptogenesis, and Neuropathology in Carboxylesterase Knockout Mice Treated with Midazolam

Abstract

Carboxylesterase knockout (ES1/) mice are more susceptible than wild-type C57BL/6 mice to the lethal effects of soman. Spontaneous recurrent seizures develop in ES1/ mice following soman-induced status epilepticus when midazolam treatment is delayed. Severe neuronal loss and neuroinflammation are present in ES1/ mice 2 weeks following soman-induced status epilepticus. ES1/ mice show acute and subchronic electroencephalography (EEG) power spectra changes after soman-induced status epilepticus and midazolam treatment is delayed.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2018
Accession Number
AD1099742

Entities

People

  • Brenda Marrero-rosado
  • Caroline R. Schultz
  • Erica Kundrick
  • Fu Du
  • Katie Walker
  • Lucille A. Lumley
  • Marcio De Araujo Furtado
  • Michael Stone
  • Sean O'brien

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticonvulsants
  • Body Weight
  • Brain
  • Brain Injuries
  • Cells
  • Central Nervous System
  • Chemical Warfare
  • Data Analysis
  • Data Science
  • Diseases And Disorders
  • Epilepsy
  • Lethal Dosage
  • Nerve Agents
  • Neurodegeneration
  • Power Spectra
  • Proteins
  • Seizures

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Neurotoxicology