Endogenous and Exogenous Pericytes in the Pathobiology and Treatment of Osteoarthritis

Abstract

Pdgfrb transgenic reporter animals represent a tool for the visualization of pericytes within joint associated tissues. Destabilization of the medial meniscus in the mouse induces osteoarthritic changes associated with dynamic changes in the vasculature and Pdgfrb reporter activity within the infrapatellar fat pad. These changes implicate endogenous pericytes as a key cellular player in post-traumatic osteoarthritis.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2020
Accession Number
AD1100257

Entities

People

  • Aaron W James

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Arthritis
  • Biomedical Research
  • Blood Vessels
  • Cartilage
  • Cells
  • Cells (Biology)
  • Connective Tissue
  • Department Of Defense
  • Disease Attributes
  • Diseases And Disorders
  • Gene Therapy
  • Growth Factors
  • Intellectual Property
  • Joint Diseases
  • Joints (Anatomy)
  • Law
  • Medical Personnel
  • Microvessels
  • Patent Applications
  • Stem Cells
  • Therapy
  • Tissues
  • Universities

Fields of Study

  • Medicine

Readers

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