Proinflammatory Epithelial Cells as a Therapeutic Target in Chronic Pancreatitis
Abstract
The focus of our study is the role of de-differentiated exocrine acinar cells in perpetuating inflammation and tissue injury in chronic pancreatitis. We hypothesize that the pro-differentiation transcription factor Ptf1a promotes recovery from acute pancreatitis, in part through secretion of anti-inflammatory signals such as FGF21, and that downregulation of Ptf1a in chronic pancreatitis leads to sustained inflammation. We have made only limited progress, unfortunately, although the personnel issues that affected us in the beginning of the project have been resolved. We have a large series of experimental mouse samples harvested and fixed, ready to analyze as work on campus begins to resume (we have moved to a partially-open status this month).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2020
- Accession Number
- AD1100265
Entities
People
- L. Charles Murtaugh
Organizations
- University of Utah