Validating Epigenetic and Genetic Biomarkers for Diagnosis of Bladder Pain of Interstitial Cystitis

Abstract

The goal of this study is to determine the biosignature consisting of DNA methylation and gene expression status detected in urine from interstitial cystitis/painful bladder syndrome (IC) patients will stratify IC patients from healthy controls. In this funding year, we have focused on (1) identification on baseline of urine collection, (2) expansion of database for better urine biomarker discovery, and (3) technology application to further identify the DNA methylation markers associated with IC. In particular, we were able to optimize the DNA methylation and gene expression assays, which were designed for high throughput screening (HTS).

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1100286

Entities

People

  • Jayoung Kim

Organizations

  • Cedars-Sinai Medical Center

Tags

Communities of Interest

  • Cyber

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Computational Science
  • Data Mining
  • Data Storage Systems
  • Health Services
  • Information Science
  • Machine Learning
  • Medical Personnel
  • Metabolism
  • Network Science
  • Pain
  • Proteins
  • Supervised Machine Learning

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology