Understanding the Connection between Traumatic Brain Injury and Alzheimer's disease: A Population-Based Medical Record Review Analysis
Abstract
The most accurate and reliable study design to determine whether the occurrence of TBI increases risk for the development of Alzheimers disease and related disorders (ADRD) is to identify incident TBI events by medical record review within a defined population and classify each by injury severity, identify matched referents within that same population, and follow both cohorts over time to observe incidence rates of ADRD. Scope: Our approach significantly reduces the methodological problems of referral and recall bias, and selective survival, which have limited the scientific communitys ability to determine whether TBI is indeed associated with an increased risk of ADRD. There are no published reports of a population-based analysis matching TBI cases, identified by medical record review and classified by injury severity, to population-based referents with non-head trauma. This is particularly important as non-head trauma may also increase the risk of ADRD. Major Findings: TBI is associated with increased risk for ADRD in an injury severity-dependent manner, particularly in men; an age effect for ADRD was observed only for Definite TBI in those <70 years at the time of TBI; no associations were found between any TBI severity and either Alzheimers disease, vascular dementia or Parkinsons disease; considering non-brain trauma consistently increased the association between TBI and developing neurodegenerative disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2020
- Accession Number
- AD1102997
Entities
People
- Allen W. Brown