Commensal Bacteria with High Homology to Nonmutated Tumor Antigens May Prevent Clinically Effective Vaccination in Breast Cancer
Abstract
We previously found a significant association of numerous sequence homologies to bacterial species found in the gut microbiome with IL-10-inducing Class II epitopes to tumor antigens and hypothesized that those microbial/tumor antigen-specific T-cells will prevent an anti-tumor immune response from developing. Aim 1 is 90 percent complete. We have demonstrated here that T-cells specific for Pseudomonas aeruginosa and the less than 50 percent homologous tumor antigen, YB1, can traffic to an TgMMTV-neu tumor implant. The bacterial and tumor antigen cross-reactive T-cells subsequently promoted tumor growth. These results speak to a potential mechanism as to why whole protein vaccines have been unsuccessful in demonstrating anti-tumor activity in Phase III clinical trials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2020
- Accession Number
- AD1104167
Entities
People
- Mary L. Disis
Organizations
- University of Washington