The Relationship Between Brain Functioning, Behavior, and Microbiota in Autism Spectrum Disorder

Abstract

While social communication deficits are considered the hallmark of autism spectrum disorder (ASD), comorbid gastrointestinal (GI) issues are common and impair quality of life in a large subset of affected individuals. Several studies have linked these GI issues to altered gut microbial composition, or dysbiosis, in ASD. Yet research has not yet clarified how dysbiosis may be related to the core features of ASD or to the symptom heterogeneity of this disorder. A growing number of studies support the concept that gut microbiota can signal to the brain by neural, endocrine, immune, and hormonal pathways. These microbial effects on the brain may modulate outputs in behavior, as well as in autonomic and neuroendocrine function.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1105447

Entities

People

  • Emeran Mayer
  • Lisa Aziz-Zadeh

Organizations

  • University of California

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Acquisition
  • Autism
  • Data Acquisition
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Gut Microbiome
  • Institutional Review Board
  • Machine Learning
  • Medical Personnel
  • Microbiomes
  • Neuroimaging
  • Personnel Management
  • Professional Development
  • Quality Of Life
  • Rehabilitation
  • Students

Fields of Study

  • Psychology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.

Technology Areas

  • Biotechnology